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LeadR Profile


David J Glass
Regeneron
Ireland

SLR Biochemistry ScienceLeadR Reputation 100%

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Health Specialties

Main specialty  Biochemistry
Full career - Last 3 years

Main Topics

Publications and Clinical Trials


Publications - Clinical Trials

Education

Academic Background

Source: ORCID

Organization

all information about organizations

Source: Pubmed

Regeneron

Regeneron (United States)

Novartis (United Kingdom)

Brandeis University

Novartis (United States)

Novartis (Netherlands)

Awards and Honors

Source: ORCID

Academic Societies

Source: ORCID

Publications Synthesis

Source: Pubmed

Number : 182

Citations

Citations: 13 593 1st author: 16 Last author: 47 Unique author: 13

Main journals

Arthritis Rheum 16
Mol Cell Biol 11
Skelet Muscle 9
Cell Metab 8
J Biol Chem 7

Best Journals

Cell 6
Nature 4
Science 2

Breakdown by type

Historic per year



Main pathologies and trends

Publications List

Quick search selection

Source: Pubmed Source: OpenAlex
Title Journal CIT SLR Year
Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis. Metabolism
38428673
0 9.8 2024
Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes. Nature
36807635
0 64.8 2023
Alfred L. Goldberg (1942-2023). Mol Cell
37419085
0 16 2023
Age-related gene expression signatures from limb skeletal muscles and the diaphragm in mice and rats reveal common and species-specific changes. Skelet Muscle
37438807
3 4.9 2023
Senescent cells damage the body throughout life. Nature
36544002
1 64.8 2022
Common and rare variant associations with clonal haematopoiesis phenotypes. Nature
36450978
30 64.8 2022
Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins. J Clin Invest
34981792
1 15.9 2022
Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis. Commun Biol
36302954
5 5.9 2022
Association of complement pathways with COVID-19 severity and outcomes. Microbes Infect
36494054
1 5.8 2022
The prevalence of low muscle mass associated with obesity in the USA. Skelet Muscle
36539856
5 4.9 2022
Activin A directly impairs human cardiomyocyte contractile function indicating a potential role in heart failure development. Front Cardiovasc Med
36440002
1 3.6 2022
Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans. Aging Cell
33512769
23 11.005 2021
Correction to: Effect of longevity genetic variants on the molecular aging rate. Geroscience
34143375
0 7.581 2021
Effect of longevity genetic variants on the molecular aging rate. Geroscience
33948810
8 7.581 2021
The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients. Mol Cell Biol
34723652
5 5.3 2021
Five-in-One: Simultaneous isolation of multiple major liver cell types from livers of normal and NASH mice. J Cell Mol Med
34558178
3 5.295 2021
Alternative complexes formed by the Escherichia coli clamp loader accessory protein HolC (x) with replication protein HolD (ψ) and repair protein YoaA. DNA Repair (Amst)
33582602
4 4.354 2021
Genetic Analysis of DinG Family Helicase YoaA and Its Interaction with Replication Clamp Loader Protein HolC in Escherichia coli. J Bacteriol
34181484
2 3.476 2021
DNA damage-signaling, homologous recombination and genetic mutation induced by 5-azacytidine and DNA-protein crosslinks in Escherichia coli. Mutat Res
33743507
2 0 2021
Frequent template switching in postreplication gaps: suppression of deleterious consequences by the Escherichia coli Uup and RadD proteins. Nucleic Acids Res
31665437
13 16.971 2020
ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY)
33378272
14 5.682 2020
Activin type II receptor signaling in cardiac aging and heart failure. Sci Transl Med
30842316
61 16.304 2019
mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4. Nat Commun
31320633
40 12.121 2019
Age-Related Gene Expression Signature in Rats Demonstrate Early, Late, and Linear Transcriptional Changes from Multiple Tissues. Cell Rep
31533046
63 8.109 2019
HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70. Cell Rep
31618641
35 8.109 2019
αKlotho Regulates Age-Associated Vascular Calcification and Lifespan in Zebrafish. Cell Rep
31509740
10 8.109 2019
The role of GDF11 in aging and skeletal muscle, cardiac and bone homeostasis. Crit Rev Biochem Mol Biol
31144559
17 7.634 2019
A serum protein signature of APOE genotypes in centenarians. Aging Cell
31385390
15 7.238 2019
Adult stem cells and regenerative medicine-a symposium report. Ann N Y Acad Sci
31655007
18 5.691 2019
Abnormal Behavior of Zebrafish Mutant in Dopamine Transporter Is Rescued by Clozapine. iScience
31325771
2 4.447 2019
Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space. Sci Rep
31253821
26 3.998 2019
Partial Inhibition of mTORC1 in Aged Rats Counteracts the Decline in Muscle Mass and Reverses Molecular Signaling Associated with Sarcopenia. Mol Cell Biol
31308131
50 3.611 2019
Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived -Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies. J Pharmacol Exp Ther
30819762
11 3.561 2019
Assessing End-of-Life Care across Settings in an Integrated Health Care Delivery System. J Palliat Med
31660780
0 2.947 2019
Safety, tolerability, and preliminary efficacy of an IGF-1 mimetic in patients with spinal and bulbar muscular atrophy: a randomised, placebo-controlled trial. Lancet Neurol
30337273
9 28.755 2018
TORC1 inhibition enhances immune function and reduces infections in the elderly. Sci Transl Med
29997249
177 17.161 2018
Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15. Cell Rep
29562191
5 7.815 2018
Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15. Cell Rep
29425507
30 7.815 2018
Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology. J Gerontol A Biol Sci Med Sci
29304191
28 4.711 2018
Protein kinase A activation inhibits gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy. J Biol Chem
29899111
19 4.106 2018
Dealing with Consequences of Irreproducibility and Modifying the Published Literature: Retractions versus Revisions. Cell Metab
29117541
0 20.565 2017
What's So Special about FGF19-Unique Effects Reported on Skeletal Muscle Mass and Function. Cell Metab
28768168
1 20.565 2017
Alterations in the in vitro and in vivo regulation of muscle regeneration in healthy ageing and the influence of sarcopenia. J Cachexia Sarcopenia Muscle
29214748
33 10.754 2017
Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proc Natl Acad Sci U S A
29109273
48 9.504 2017
ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation. Cell Rep
29241530
25 8.032 2017
Blockade of Metallothioneins 1 and 2 Increases Skeletal Muscle Mass and Strength. Mol Cell Biol
27956698
30 3.813 2017
Elevated GDF11 Is a Risk Factor for Age-Related Frailty and Disease in Humans. Cell Metab
27411004
11 18.164 2016
Ken Fearon. Cell Metab
28034417
0 18.164 2016
Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly. Aging (Albany NY)
27454226
25 4.867 2016
Α-Dystrobrevin-1 recruits Grb2 and α-catulin to organize neurotransmitter receptors at the neuromuscular junction. J Cell Sci
26769899
10 4.431 2016
Prehospital Ketamine is a Safe and Effective Treatment for Excited Delirium in a Community Hospital Based EMS System. Prehosp Disaster Med
27517801
6 0 2016
GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration. Cell Metab
26001423
239 18.164 2015
ATP citrate lyase improves mitochondrial function in skeletal muscle. Cell Metab
26039450
43 18.164 2015
Muscle RING-finger 2 and 3 maintain striated-muscle structure and function. J Cachexia Sarcopenia Muscle
27493870
26 9.697 2015
A long non-coding RNA, LncMyoD, regulates skeletal muscle differentiation by blocking IMP2-mediated mRNA translation. Dev Cell
26143994
137 9.174 2015
Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation. Mol Cell Biol
26527617
17 4.398 2015
Introduction special issue. Bone
26115912
0 4.14 2015
The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination. Mol Cell Endocrinol
26116825
27 3.754 2015
NIH grants: Focus on questions, not hypotheses. Nature
24646984
1 40.137 2014
mTOR inhibition improves immune function in the elderly. Sci Transl Med
25540326
324 16.761 2014
G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. Proc Natl Acad Sci U S A
25336758
44 9.661 2014
Treatment of sporadic inclusion body myositis with bimagrumab. Neurology
25381300
73 8.32 2014
Skeletal muscle's 3rd year anniversary. Skelet Muscle
24456943
1 3.738 2014
Clinical classification of cancer cachexia: phenotypic correlates in human skeletal muscle. PLoS One
24404136
40 3.706 2014
Deletion of atrophy enhancing genes fails to ameliorate the phenotype in a mouse model of spinal muscular atrophy. Neuromuscul Disord
24656734
8 2.969 2014
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet
23603761
172 27.959 2013
Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway. Cancer Res
23536553
29 9.122 2013
Susceptibility to childhood-onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic loci. Arthritis Rheum
23450725
21 7.871 2013
Signaling pathways controlling skeletal muscle mass. Crit Rev Biochem Mol Biol
24237131
226 6.639 2013
Rural and urban Medicare beneficiaries use remarkably similar amounts of health care services. Health Aff (Millwood)
24173368
9 4.98 2013
A new system for comparative functional genomics of Saccharomyces yeasts. Genetics
23852385
15 4.556 2013
Gαi2 signaling is required for skeletal muscle growth, regeneration, and satellite cell proliferation and differentiation. Mol Cell Biol
24298018
24 4.398 2013
An antibody blocking activin type II receptors induces strong skeletal muscle hypertrophy and protects from atrophy. Mol Cell Biol
24298022
111 4.398 2013
Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells. Am J Physiol Endocrinol Metab
24253050
22 4.142 2013
MG53's new identity. Skelet Muscle
24175977
6 3.738 2013
Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo. Cell Biochem Funct
23512667
24 2.186 2013
Cancer cachexia: mediators, signaling, and metabolic pathways. Cell Metab
22795476
522 18.164 2012
Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation. Mol Cell
22902555
32 14.714 2012
Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap. Ann Rheum Dis
22294642
21 12.811 2012
An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis. Dev Cell
23177649
81 9.174 2012
Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope. Arthritis Rheum
21953520
21 7.477 2012
Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. Arthritis Rheum
22354554
28 7.477 2012
Multiple juvenile idiopathic arthritis subtypes demonstrate proinflammatory IgG glycosylation. Arthritis Rheum
22549726
15 7.477 2012
MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle. Sci Signal
22337810
21 6.83 2012
Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia. Mol Cell Biol
23109432
124 4.398 2012
Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism. Mol Cell Biol
22586266
55 4.398 2012
TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin A. Skelet Muscle
22313861
55 3.738 2012
Skeletal Muscle - one year on. Skelet Muscle
22221535
1 3.738 2012
Se-Jin Lee, myostatin discoverer, elected to the National Academy of Science. Skelet Muscle
22676848
0 3.738 2012
Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nat Genet
22200769
26 27.959 2011
Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB. Circ Res
21617130
35 13.965 2011
Molecular mechanisms and treatment options for muscle wasting diseases. Annu Rev Pharmacol Toxicol
20936944
57 12.877 2011
Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis. Ann Rheum Dis
21515602
26 12.811 2011
Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template. Mol Syst Biol
21811230
79 9.75 2011
The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling. Dev Cell
22033112
73 9.174 2011
Gαi2 signaling promotes skeletal muscle hypertrophy, myoblast differentiation, and muscle regeneration. Sci Signal
22126963
38 6.83 2011
Welcome to skeletal muscle. Skelet Muscle
21798079
3 3.738 2011
Treating cancer cachexia to treat cancer. Skelet Muscle
21798080
27 3.738 2011
Electrical impedance as a novel biomarker of myotube atrophy and hypertrophy. J Biomol Screen
21493966
13 0 2011
A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis. Arthritis Rheum
20533289
15 8.435 2010
Biologic similarities based on age at onset in oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis. Arthritis Rheum
20662067
25 8.435 2010
Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects. Arthritis Rheum
20191588
52 8.435 2010
The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1. Arthritis Rheum
20722033
60 8.435 2010
Heterogeneity in juvenile idiopathic arthritis: impact of molecular profiling based on DNA polymorphism and gene expression patterns. Arthritis Rheum
20496366
4 8.435 2010
A critique of the hypothesis, and a defense of the question, as a framework for experimentation. Clin Chem
20511448
9 8.008 2010
The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice. J Cell Biol
20308426
105 7.955 2010
Voluntary running, skeletal muscle gene expression, and signaling inversely regulated by orchidectomy and testosterone replacement. Am J Physiol Endocrinol Metab
21045173
37 4.142 2010
Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis. Arthritis Res Ther
20576155
28 4.121 2010
Signaling pathways perturbing muscle mass. Curr Opin Clin Nutr Metab Care
20397318
151 4.023 2010
PI3 kinase regulation of skeletal muscle hypertrophy and atrophy. Curr Top Microbiol Immunol
20593312
142 3.719 2010
Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype. Pharmacogenet Genomics
20827233
22 2.184 2010
Sequence feature variant type (SFVT) analysis of the HLA genetic association in juvenile idiopathic arthritis. Pac Symp Biocomput
19908388
10 0 2010
During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. J Cell Biol
19506036
271 7.955 2009
Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size. Am J Physiol Cell Physiol
19357233
324 3.602 2009
Muscle ring finger 1 mediates cardiac atrophy in vivo. Am J Physiol Heart Circ Physiol
19168726
61 3.348 2009
A brief history of the hypothesis. Cell
18692458
11 30.41 2008
Ethical and practical issues associated with aggregating databases. PLoS Med
18816162
15 11.862 2008
Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritis. Arthritis Rheum
18576317
5 8.435 2008
Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms. Arthritis Rheum
18759271
60 8.435 2008
Biochemical markers of bone turnover associated with calcium supplementation in children with juvenile rheumatoid arthritis: results of a double-blind, placebo-controlled intervention trial. Arthritis Rheum
19035501
8 8.435 2008
Inferring adaptive regulation thresholds and association rules from gene expression data through combinatorial optimization learning. IEEE/ACM Trans Comput Biol Bioinform
17975273
4 1.955 2008
Integration of genomic data for inferring protein complexes from global protein-protein interaction networks. IEEE Trans Syst Man Cybern B Cybern
18270078
7 0 2008
The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle. Cell Metab
17983583
284 18.164 2007
Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo. Circ Res
17272810
105 13.965 2007
Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins. J Clin Invest
17965779
119 12.784 2007
Two tales concerning skeletal muscle. J Clin Invest
17786235
7 12.784 2007
Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3. J Clin Invest
17786241
132 12.784 2007
Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis. Diabetes
17303803
44 8.684 2007
A randomized controlled trial of calcium supplementation to increase bone mineral density in children with juvenile rheumatoid arthritis. Arthritis Rheum
16802360
13 8.435 2006
Conditional activation of MET in differentiated skeletal muscle induces atrophy. J Biol Chem
17194700
14 5.328 2006
The DEK nuclear autoantigen is a secreted chemotactic factor. Mol Cell Biol
17030615
50 4.398 2006
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. Nat Med
15654325
86 29.886 2005
A signaling role for dystrophin: inhibiting skeletal muscle atrophy pathways. Cancer Cell
16286242
12 27.407 2005
Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis. Arthritis Rheum
15641089
22 8.435 2005
Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case-control study. Arthritis Res Ther
15743475
5 4.121 2005
Skeletal muscle hypertrophy and atrophy signaling pathways. Int J Biochem Cell Biol
16087388
366 3.505 2005
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell
15479644
551 30.41 2004
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell
15125842
730 14.714 2004
Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway. J Biol Chem
15550386
197 5.328 2004
Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy. Mol Cell Biol
15485899
168 4.398 2004
Signalling pathways that mediate skeletal muscle hypertrophy and atrophy. Nat Cell Biol
12563267
231 20.06 2003
Molecular mechanisms modulating muscle mass. Trends Mol Med
12928036
133 10.732 2003
The -174G allele of the interleukin-6 gene confers susceptibility to systemic arthritis in children: a multicenter study using simplex and multiplex juvenile idiopathic arthritis families. Arthritis Rheum
14613283
41 8.435 2003
Increased prevalence of familial autoimmunity in simplex and multiplex families with juvenile rheumatoid arthritis. Arthritis Rheum
12124869
45 8.435 2002
Mapping sites responsible for interactions of agrin with neurons. J Neurochem
12423238
26 4.083 2002
Identification of ubiquitin ligases required for skeletal muscle atrophy. Science
11679633
1346 37.205 2001
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol
11715023
974 20.06 2001
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol
11715022
581 20.06 2001
Assessing phytoremediation's progress in the United States and Europe. Environ Sci Technol
11718366
12 6.198 2001
Agrin and microvascular damage in Alzheimer's disease. Neurobiol Aging
10867220
56 5.117 2000
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science
10576741
228 37.205 1999
Agrin in Alzheimer's disease: altered solubility and abnormal distribution within microvasculature and brain parenchyma. Proc Natl Acad Sci U S A
10339611
28 9.661 1999
Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations. J Cell Biol
10477765
58 7.955 1999
Distinct phenotypes of mutant mice lacking agrin, MuSK, or rapsyn. Brain Res Dev Brain Res
10320756
27 0 1999
Localization and regulation of MuSK at the neuromuscular junction. Dev Biol
9698449
29 2.944 1998
An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Mol Cell
9659900
192 14.714 1997
Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold. Neuron
9136771
87 14.024 1997
Kinase domain of the muscle-specific receptor tyrosine kinase (MuSK) is sufficient for phosphorylation but not clustering of acetylcholine receptors: required role for the MuSK ectodomain? Proc Natl Acad Sci U S A
9238066
30 9.661 1997
Laminin-induced acetylcholine receptor clustering: an alternative pathway. J Cell Biol
9314538
36 7.955 1997
Sequential roles of agrin, MuSK and rapsyn during neuromuscular junction formation. Curr Opin Neurobiol
9232805
21 6.133 1997
Hepatocyte growth factor promotes motor neuron survival and synergizes with ciliary neurotrophic factor. J Biol Chem
9030587
27 4.125 1997
Agrin acts via a MuSK receptor complex. Cell
8653787
214 30.41 1996
The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo. Cell
8653786
294 30.41 1996
Assessment of coercive and noncoercive pressures to enter drug abuse treatment. Drug Alcohol Depend
8889406
12 3.222 1996
Structural determinants of Trk receptor specificities using BDNF-based neurotrophin chimeras. J Neurosci Res
8951673
0 2.481 1996
The receptor tyrosine kinase MuSK is required for neuromuscular junction formation and is a functional receptor for agrin. Cold Spring Harb Symp Quant Biol
9246472
15 0 1996
Naturally occurring tyrosine kinase inserts block high affinity binding of phospholipase C gamma and Shc to TrkC and neurotrophin-3 signaling. J Biol Chem
7657612
10 4.125 1995
The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins. Neuron
8043276
63 14.024 1994
Legal issues in the assessment and treatment of individuals with dual diagnoses. J Consult Clin Psychol
8034829
0 4.593 1994
The neurotrophins and their receptors. Trends Cell Biol
14731744
19 15.333 1993
Alternative forms of rat TrkC with different functional capabilities. Neuron
8494647
81 14.024 1993
Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron
7679912
115 14.024 1993
Tissue-specific alternative splicing generates two isoforms of the trkA receptor. J Biol Chem
8325889
49 4.125 1993
K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses. Mol Biol Cell
1323351
37 3.685 1992
Cloning and analysis of neurotrophic factor receptors using function-based strategies. Cold Spring Harb Symp Quant Biol
1339690
0 0 1992
TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor. Cell
1649703
37 30.41 1991
trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Cell
1710174
139 30.41 1991
Agricultural biotechnology: occupational health and regulatory issues. Occup Med
2047979
0 0 1991
Isolation and characterization of flat revertant cell lines from A-MuLV-transformed fibroblasts. Oncogene Res
2157187
1 0 1990
States noticing field releases. Biotechnology (N Y)
1366933
0 0 1990
Conserved sequences and transcription of the hsp70 gene family in Trypanosoma brucei. Mol Cell Biol
3796613
41 4.398 1986
Variant surface glycoprotein gene expression site switches in Trypanosoma brucei. J Biol Chem
3009443
9 4.125 1986

Clinical Trials 4 Source:  ClinicalTrials

Synthesis

By phase:

Phase 2 2
Phase 1 1
Phase 2/Phase 3 1

By status:

Completed 4

By Monocentric/Multicentric:

monocentric 2
multicentric2to4 0
multicentric5to9 1
multicentricup10 1

Main Topics

Congenital, Hereditary, and Neonatal Diseases and Abnormalities 1
Immune System Diseases 1
Musculoskeletal Diseases 1
Nervous System Diseases 1
Respiratory Tract Diseases 1
Skin and Connective Tissue Diseases 1

Cohort/Consortium Investigators 0

Drugs and Sponsors Source: ClinicalTrials

All Clinical Trials information

Clinical Trials Breakdown information Source: ClinicalTrials

Breakdown by Phase

Breakdown by Status

Breakdown by Mono/Multi Centric

Percentage of internationnal

Clinical Trials Timeline Source: ClinicalTrials

Studies Phases and Years

Clinical Trials List Source: ClinicalTrials

Quick search selection

NCTID - Title Phase Status Year

NCT04315298

Evaluation of the Efficacy and Safety of Sarilumab in Hospitalized Patients With COVID 19
Phase 2/Phase 3 Completed 2020

NCT03115996

Study of the Safety Tolerability Pharmacokinetics and Pharmacodynamics of REGN3918 in Healthy Volunteers
Phase 1 Completed 2017

NCT02024932

Safety Tolerability and Efficacy of BVS857 in Patients With Spinal and Bulbar Muscular Atrophy
Phase 2 Completed 2014

NCT00000429

Calcium Supplements for Bone Health in Juvenile Rheumatoid Arthritis
Phase 2 Completed 1996

LeadR Networks Source: Pubmed Source: ClinicalTrials

Main global connection map



Nb Contacts:
Country Contact count
United States 322
United Kingdom 57
Switzerland 43
Germany 33
Ireland 26
Canada 11
Italy 11
Australia 10
India 6
Netherlands 6
Japan 5
France 4
Poland 4
Sweden 4
Denmark 3
Mexico 3
Luxembourg 2
New Zealand 2
Spain 2
Austria 1
Brazil 1
Colombia 1
Czechia 1
Romania 1
Russia 1
Singapore 1
Turkey 1

LeadR Networks Source: Pubmed Source: ClinicalTrials

Graph connection

LeadR Networks Source: Pubmed Source: ClinicalTrials

Connection list

Name Organization Country Linked
Yancopoulos George D Regeneron (United States) United States 35
Thompson Susan D Cincinnati Children's Hospital Medical Center United States 19
Stitt Trevor N Regeneron (United States) United States 14
Valenzuela David M Regeneron Ireland 8
Trendelenburg Anne-Ulrike Novartis (United Kingdom) United Kingdom 8
Patterson Cam University of Arkansas for Medical Sciences United States 7
Lach-Trifilieff Estelle Novartis (Switzerland) Switzerland 7
Willis Monte S Indiana University School of Medicine United States 7
Sanes Joshua R Harvard University United States 6
Cadena Silvia Maria Suter Correia Hospital Adventista Silvestre Brazil 6
Shavlakadze Tea Novartis (United Kingdom) United Kingdom 6
De Chiara Thomas M Northwestern University (United States) United States 6
Roubenoff Ronenn Tufts University School Of Medicine United States 6
Morvan Frederic Novartis (Switzerland) Switzerland 6
Jennings Lori L Novartis (United States) United States 5
Prahalad Sampath Emory University United States 5
Grom Alexei A Cincinnati Children's Hospital Medical Center United States 5
Feige Jerome N École Polytechnique Fédérale de Lausanne Switzerland 5
Hatakeyama Shinji Novartis (Switzerland) Switzerland 5
Morton Lori Regeneron (United States) United States 5
Ibebunjo Chikwendu Novartis (United Kingdom) United Kingdom 5
Zhang Yunyu Novartis (United Kingdom) United Kingdom 5
Fornaro Mara Novartis (Switzerland) Switzerland 5
Sebastiani Paola Tufts Medical Center United States 4
Perls Thomas T Boston University United States 4